Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA)
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چکیده
منابع مشابه
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.
In this study, we investigated the role of the inducible form of heat shock protein 70 (hsp70) in the presentation of the major putative autoantigen in multiple sclerosis, myelin basic protein (MBP), in the context of appropriate MHC class II. By coimmunoprecipitation, we found that MBP is associated with hsp70 in APC in an ATP/ADP-dependent manner. Additionally, using confocal microscopy, hsp7...
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The ubiquitous small heat shock proteins (sHSPs) are well documented to act in vitro as molecular chaperones to prevent the irreversible aggregation of heat-sensitive proteins. However, the in vivo activities of sHSPs remain unclear. To investigate the two most abundant classes of plant cytosolic sHSPs (class I [CI] and class II [CII]), RNA interference (RNAi) and overexpression lines were crea...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2010
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-010-0184-z